According to research studies, stress management can promote methylation support. High levels psychological and physiological stress can increase the production of the catecholamines epinephrine and norepinephrine, both of which depend on methylation for their biosynthesis, metabolism, and excretion. DNA methylation activity utilizes SAMe and it can lower the availability of this methyl donor for other processes. Stress management is, therefore, a fundamental treatment option to promote methylation support.

Stress can also affect DNA methylation status through different mechanisms rather than through the utilization of methyl donors. Although a variety of research studies have been conducted regarding the effects of stress on methylation, our understanding of the complex association between stress management and methylation support is still tremendously limited. Methylation of the promoter genes for glucocorticoid, an essential regulator of the HPA axis and stress response, has been demonstrated to be affected differently through various states of stress, including early-life stress, post-traumatic stress disorder, or PTSD, and chronic fatigue syndrome.

How Stress Affects Methylation

We do understand, however, that stress-mediated epigenetic “priming” through methylation during fundamental developmental stages has been associated with a variety of health issues. By way of instance, and as we’ve previously discussed, low levels of maternal nurturing can affect DNA methylation status in the glucocorticoid receptor promoter and gene expression. This ultimately suggests that traumatic experiences, especially during essential stages of development, may “prime” high levels of stress. Several researchers believe that the connection between stress and methylation may explain the association of health issues, such as asthma.

Furthermore, research studies determined that prenatal maternal stress, as evaluated after the January 1998 Quebec ice storm, correlates with increased central adiposity and BMI in offspring at age 13 1⁄2. These changes are regulated through DNA methylation. Traumatic childhood experiences, including maltreatment, and parental death or desertion, outside of the prenatal and perinatal stages of development can also affect methylation of the promoter genes for glucocorticoid, associated with increased cortisol production.

Research studies have also demonstrated that acute and chronic stress can increase circulating inflammatory factors, including IL-1β, CRP, and IL-6, which are commonly regulated through the NLRP3 inflammasome. This may be a considerable way in which stress affects epigenetic changes. The effects of inflammation on DNA methylation status and activity have been discussed in previous articles. Doctors and functional medicine practitioners can recommend stress management techniques for methylation support.

Stress is a natural response to any type of demand or threat, it is the human body’s way of protecting you. However, chronic stress can cause a variety of health issues and recent research studies have demonstrated that stress can even affect an individual’s DNA methylation status. Doctor and functional medicine practitioners can recommend several stress management techniques, whether through nutrition and/or lifestyle modifications, to help promote methylation support. According to the article above, stress can affect methylation in several ways.

Dr. Alex Jimenez D.C., C.C.S.T. Insight

Smoothies and Juices for Methylation Support

While many healthcare professionals can recommend nutritional guidelines and lifestyle modifications to improve methylation support, there are several options you can try yourself at home. As described above, methylation support supplementation should be determined by a healthcare professional. Smoothies and juices are a fast and easy way to include all the necessary nutrients you need for methylation support without any side-effects. The smoothies and juices below are part of the Methylation Diet Food Plan.

Sea Green Smoothie
Servings: 1
Cook time: 5-10 minutes
• 1/2 cup cantaloupe, cubed
• 1/2 banana
• 1 handful of kale or spinach
• 1 handful of Swiss chard
• 1/4 avocado
• 2 teaspoons spirulina powder
• 1 cup water
• 3 or more ice cubes
Blend all ingredients in a high-speed blender until completely smooth and enjoy!

Berry Bliss Smoothie
Servings: 1
Cook time: 5-10 minutes
• 1/2 cup blueberries (fresh or frozen, preferably wild)
• 1 medium carrot, roughly chopped
• 1 tablespoon ground flaxseed or chia seed
• 1 tablespoons almonds
• Water (to desired consistency)
• Ice cubes (optional, may omit if using frozen blueberries)
Blend all ingredients in a high-speed blender until smooth and creamy. Best served immediately!

Sweet and Spicy Juice
Servings: 1
Cook time: 5-10 minutes
• 1 cup honeydew melons
• 3 cups spinach, rinsed
• 3 cups Swiss chard, rinsed
• 1 bunch cilantro (leaves and stems), rinsed
• 1-inch knob of ginger, rinsed, peeled and chopped
• 2-3 knobs whole turmeric root (optional), rinsed, peeled and chopped
Juice all ingredients in a high-quality juicer. Best served immediately!

Ginger Greens Juice
Servings: 1
Cook time: 5-10 minutes
• 1 cup pineapple cubes
• 1 apple, sliced
• 1-inch knob of ginger, rinsed, peeled and chopped
• 3 cups kale, rinsed and roughly chopped or ripped
• 5 cups Swiss chard, rinsed and roughly chopped or ripped
Juice all ingredients in a high-quality juicer. Best served immediately!

Zesty Beet Juice
Servings: 1
Cook time: 5-10 minutes
• 1 grapefruit, peeled and sliced
• 1 apple, washed and sliced
• 1 whole beet, and leaves if you have them, washed and sliced
• 1-inch knob of ginger, rinsed, peeled and chopped
Juice all ingredients in a high-quality juicer. Best served immediately!

Protein Power Smoothie
Serving: 1
Cook time: 5 minutes
• 1 scoop protein powder
• 1 tablespoon ground flaxseed
• 1/2 banana
• 1 kiwi, peeled
• 1/2 teaspoon cinnamon
• Pinch of cardamom
• Non-dairy milk or water, enough to achieve desired consistency
Blend all ingredients in a high-powered blender until completely smooth. Best served immediately!

ProLon® Fasting Mimicking Diet

Balanced methylation support can be achieved through proper nutrition. The ProLon® fasting mimicking diet offers a 5-day meal program which has been individually packed and labeled to serve the foods you need for the FMD in precise quantities and combinations. The meal program is made up of ready-to-eat or easy-to-prepare, plant-based foods, including bars, soups, snacks, supplements, a drink concentrate, and teas. The products are scientifically formulated and great tasting. Before starting the ProLon® fasting mimicking diet, 5-day meal program, please make sure to talk to a healthcare professional to find out if the FMD is right for you. The ProLon® fasting mimicking diet can help promote methylation support, among a variety of other healthy benefits.

Many healthcare professionals can recommend a variety of treatment options to help with stress management and help prevent health issues associated with DNA methylation. Proper nutrition and lifestyle habits, can improve methylation. The scope of our information is limited to chiropractic, musculoskeletal and nervous health issues as well as functional medicine articles, topics, and discussions. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 .

Curated by Dr. Alex Jimenez

Additional Topic Discussion: Acute Back Pain

Back pain is one of the most prevalent causes of disability and missed days at work worldwide. Back pain attributes to the second most common reason for doctor office visits, outnumbered only by upper-respiratory infections. Approximately 80 percent of the population will experience back pain at least once throughout their life. Your spine is a complex structure made up of bones, joints, ligaments, and muscles, among other soft tissues. Injuries and/or aggravated conditions, such as herniated discs, can eventually lead to symptoms of back pain. Sports injuries or automobile accident injuries are often the most frequent cause of back pain, however, sometimes the simplest of movements can have painful results. Fortunately, alternative treatment options, such as chiropractic care, can help ease back pain through the use of spinal adjustments and manual manipulations, ultimately improving pain relief.

Formulas for Methylation Support

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