Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Scientists Inhibit Brain Tumor Cell Growth, Paving Way for New Treatment | Circle of Docs

Glioblastoma is a particularly aggressive form of brain cancer that can be difficult to treat. New research, however, may have found a drug that can inhibit the protein driving its growth.
Researchers may have found a way to inhibit the growth of brain tumors, here shown in an MRI scan.
Glioblastomas are tumors that form out of the “sticky,” supportive tissue of the brain and spinal cord.

Most of the time, glioblastomas are aggressive malignant; they are made of many different types of cells that reproduce very quickly and receive a significant blood supply. The 5-year survival rate is estimated to be less than 10 percent.

Glioblastoma can be difficult to treat because of the heterogenous nature of its cells. Some of the cells may respond to therapy while others may not.

Typically, treatment includes a combination of surgery, radiation, and chemotherapy. So far, this has resulted in a median survival of about 2 to 3 years for patients receiving standard treatment.

Patients with more severe forms of glioblastoma, who receive a combination of drugs and radiation therapy, usually survive for an average of 14.6 months, and the 2-year survival rate is approximately 30 percent. Little can be done to treat recurrent glioblastoma.

In this context, more and more researchers are exploring genetic options for treatment. Recent studies have pointed to mutations in the receptor tyrosine kinase (RTK) genes as the key driver of glioblastoma, but clinical trials aimed specifically at neutralizing these driver mutations were not successful in treating this form of cancer.

However, researchers from the Peter O’Donnell Jr. Brain Institute and Harold C. Simmons Comprehensive Cancer Center may have found a way to inhibit glioblastoma cells.

Their findings were published in the journal Cell Reports.

The team – co-led by Dr. Robert Bachoo, of the Annette G. Strauss Center for Neuro-Oncology at University of Texas Southwestern Medical Center, and Dr. Ralf Kittler, an assistant professor of pharmacology in the Eugene McDermott Center for Human Growth and Development – successfully used a drug to target different proteins that drive the growth of glioblastoma tumors.

Mithramycin inhibits glioblastoma-driving transcription factors

The new study suggests that so far, researchers have mistakenly focused on RTK gene mutations, which are only responsible for starting tumor growth, not for the continued growth of glioblastoma.

“Our work shows that the gene mutations which the pharmaceutical industry and clinicians have been focusing on are essential only for starting tumor growth. Once the tumor has advanced to the stage where patients seek treatment, these mutations are no longer required for continued tumor growth; they are in effect redundant,” explains co-senior author Dr. Bachoo.

Instead of the RTK genes, the new study found three transcription factors to be responsible for glioblastoma: Sox2, Olig2, and Zeb1.

As co-senior author Dr. Kittler explains, the study shows that these “neurodevelopmental transcription factors (master proteins that regulate the activity of hundreds of genes during normal brain development) are reactivated to drive the growth of glioblastoma.”

Dr. Alex Jimenez D.C.,C.C.S.T’s insight:

Glioblastoma can be difficult to treat because of the heterogenous nature of its cells. Some of the cells may respond to therapy while others may not.

Typically, treatment includes a combination of surgery, radiation, and chemotherapy. So far, this has resulted in a median survival of about 2 to 3 years for patients receiving standard treatment.

Now, there is hope. These new studies reveal that limiting transitional factors are a key to preventing cellular growth. This offers a great opportunity of discovery for those suffering with certain forms of brain tumors. 

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PUSH-as-Rx ®™ Beyond Rehabilitation For All - No Matter The Age

Functional Rehabilitation El Paso Chiropractor
Injury & Functional Fitness Rehabiliation Center: Taking Functional Recovery To A New Level - No Matter Age or Impairment.

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Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal, and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the cities premier doctors, therapists and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, un-wanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

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The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 Read More…

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