Dr. Alex Jimenez, El Paso's Chiropractor
I hope you have enjoyed our blog posts on various health, nutritional and injury related topics. Please don't hesitate in calling us or myself if you have questions when the need to seek care arises. Call the office or myself. Office 915-850-0900 - Cell 915-540-8444 Great Regards. Dr. J

Methylcobalamin Effects on Diabetic Neuropathy

Methylcobalamin is an active form of vitamin B12 and has been used as a therapeutic adjuvant to treat multiple chronic conditions. In fact, methylcobalamin modulates the synthesis of methionine and S-adenosylmethionine. It has been a part of diabetic neuropathy treatment with positive results and can alleviate the pain sensation.

Daily intake of methylcobalamin is necessary because the human body is not able to synthesize it. Therefore methylcobalamin is considered essential. Besides, it is the only form of vitamin B12 that can cross the blood-brain barrier without transformation.

Neurological benefits of methylcobalamin

The methyl groups donated by methylcobalamin stimulated serotonin production, which in turn enhances mood and exerts protection against excitotoxins.

Converts homocysteine to methionine and reduces the risk of vascular diseases, arterial sclerosis, and strokes. Also, 5-methyltetrahydrofolate is an important element to eliminate homocysteine. Vitamin supplements reduce the chances of building homocysteine associated with stress.

Without methylcobalamin, myelin could not be formed.

Methylcobalamin produces S-adenosylmethionine. This compound promotes mitochondrial energy. This promotes better use of fats and carbohydrates in the metabolic process and makes them available for energy production.

Therapeutic applications of methylcobalamin:

 

The supplementation of methylcobalamin to treat a multitude of clinical conditions has been extensively reported. Indeed, its use to ameliorate diabetic neuropathy has been recognized, as well as its beneficial effects on rheumatoid arthritis and dementia. The exertion of these benefits relies on methylcobalamin’s capacity to regenerate the injured nerves, as it promotes cell growth and replication linked to proper neuronal functioning.

Nevertheless, methylcobalamin supplementation has been linked to reduced pain sensation caused by diabetic neuropathy, lower back pain, and neuralgia.

Diabetic peripheral neuropathy

 

The prevalence of diabetic peripheral neuropathy (DPN) is around 30-50%, and it is considered the most common chronic complication of diabetes. DPN commonly presents with pain and symmetrical polyneuropathy. It can easily develop with pain, sensory or motor disorders, and numbness.

DPN’s diagnosis is commonly made by reviewing clinical symptoms, a physical test, and the patient’s medical history. Nonetheless, the medical test may include an examination of:

  • Overall muscle strength and tone
  • Tendon reflexes
  • Sensitivity to touch and vibration

Specific tests to help diagnose diabetic neuropathy:

  • Filament test. Your doctor will brush a soft nylon fiber (monofilament) over areas of your skin to test your sensitivity to touch.
  • Sensory testing. This non-invasive test is used to tell how your nerves respond to vibration and changes in temperature.
  • Nerve conduction testing. This test measures how quickly the nerves in your arms and legs conduct electrical signals. It’s often used to diagnose carpal tunnel syndrome.
  • Muscle response testing. Called electromyography, this test is often done with nerve conduction studies. It measures electrical discharges produced in your muscles.
  • Autonomic testing. Special tests may determine how your blood pressure changes while you are in different positions and whether you sweat normally.

An association between the prolonged treatment with metformin and a deficiency of vitamin B12 in diabetic patients has been reported, leading to a higher prevalence of methylcobalamin deficiency.

Vitamin B12, methylcobalamin with and without other vitamins and microelements have been supplemented to measure pain sensation and regenerate nerve function improvements. Nevertheless, the underlying reason to perform these large cohort studies is to reduce the secondary effects of tricyclic antidepressants and opioid or opioid-like analgesics. It is also fair to mention that while these medications may aid the pain sensation, there is no myelin production or motor nerve fiber regeneration linked to these drugs. Therefore, the treatment or supplementation of methylcobalamin can treat the condition’s root cause and decrease pain sensation.

A study aimed to review the effectiveness of vit B12 on DPN, that included 4 relevant qualified articles showed interesting results. In one of the studies, nerve conduction velocity improved significantly after the intervention. All of the studies reported a decrease in pain symptomatology and better scores in the testing assessments compared to the control groups.

To conclude on a high note, several supplements are being tested and studied to be part of the medical treatment of DPN. They are all being compared to the beneficial effects conferred by methylcobalamin. In fact, methylcobalamin has been approved by the China Food and Drug Administration for treating peripheral neuropathy and is recommended in the Chinese guideline for type 2 diabetes.

Pharmacokinetics and Dosage

Methylcobalamin’s intake can be administered orally, in the form of a nasal spray (9% bioavailability), muscular injection, or parenterally. This compound needs to be bind to an intrinsic factor, which is made in the stomach, and later it is absorbed by the distal ileum. Furthermore, methylcobalamin gets bound and distributed to every cell by Transcobalamine II. It could be stored in the liver in an amount of 300-500 micrograms, and then it is eliminated via bile.

Dosage:
Stress relief 500 mcg/day
Acute cases of neuropathy 1500mcg/day
Age-related brain decay 1mg/day
Vegetarian diet-related vit B12 deficiency 100mg/day
Basic nerve support 3mg/day

ANTI-INFLAMMATORY GEN(I)E

Cauliflower is all the rage right now, and it is clear to see. Nutritionally speaking is a great source of glucosinolates- linked to preventing cancer, vitamin K, and vitamin C.  If you are trying to cut some carbs and keep your glucose in check, try this cauliflower rice!

Cauliflower Rice

Servings: 4
Cook time: 15-20 minutes

  • 1 head of cauliflower, roughly chopped into medium-sized pieces
  • 4 tablespoon extra virgin olive oil
  • 1 teaspoon salt

Place the cauliflower into a food processor and pulse until the texture resembles rice.

Heat the oil in a large skillet.

Add the cauliflower and salt, or use garlic to bring up the flavor.

Stir and cook evenly in the pan (about 8-12 minutes). Serve hot and with your favorite meal. -Ana Paola Rodríguez Arciniega

References

Gupta, J. K., and Qureshi Shaiba Sana. “Potential benefits of methylcobalamin: A review.” Austin J Pharmacol Ther 3.3 (2015): 1076.

Jayabalan, Bhavani, and Lian Leng Low. “Vitamin B supplementation for diabetic peripheral neuropathy.” Singapore medical journal 57.2 (2016): 55.

Jia, Hai-yan, Hao-ming Tian, and Dong Wei. “Effects of Methylcobalamin on diabetic peripheral neuropathy: a systematic review.” Chinese J Evid Based Med 5 (2005): 609-618.

https://www.mayoclinic.org/diseases-conditions/diabetic-neuropathy/diagnosis-treatment/drc-20371587#:~:text=A%20doctor%20can%20usually%20diagnose,Tendon%20reflexes

 

 

Additional Online Links & Resources (Available 24/7)



Online Appointments or Consultations:  https://bit.ly/Book-Online-Appointment

Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History

Online Functional Medicine Assessment: https://bit.ly/functionmed

Disclaimer

The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us 915-850-0900 Read More…

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, CTG*

email: coach@elpasofunctionalmedicine.com
phone: 915-850-0900
Licensed in Texas & New Mexico

Leave A Reply

Your email address will not be published.

This site uses Akismet to reduce spam. Learn how your comment data is processed.

PUSH-as-Rx ®™ Beyond Rehabilitation For All - No Matter The Age

Functional Rehabilitation El Paso Chiropractor
Injury & Functional Fitness Rehabiliation Center: Taking Functional Recovery To A New Level - No Matter Age or Impairment.

Again,  We Welcome You 👊🏻.

Our Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal, and soft tissue injuries.

We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training and Rehabilitation Systems for all ages.

As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises, and advanced agility treatment options. We have teamed up with the cities premier doctors, therapists and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.

We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.

Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, un-wanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.

With a bit of work, we can achieve optimal health together, no matter the age or disability.

Join us in improving your health for you and your family.

It’s all about: LIVING, LOVING & MATTERING! 🍎

Welcome & God Bless

EL PASO LOCATIONS

Central:
6440 Gateway East, Ste B
Phone: 915-850-0900

East Side:
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677

Clinic Location 1

Address: 11860 Vista Del Sol Dr Suite 128
El Paso, TX 79936
Phone: (915) 412-6677
Email: Send Email
Web: www.DrAlexJimenez.com

Clinic Location 2

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 850-0900
Email: Send Email
Web: www.ElPasoBackClinic.com

Clinic Location 3

Address: 1700 N Zaragoza Rd # 117
El Paso, TX 79936
Phone: (915) 850-0900
Email: Send Email
Web: www.ChiropracticScientist.com

Push As Rx Crossfit & Rehab

Address: 6440 Gateway East, Building B
El Paso, TX 79905
Phone: (915) 412-6677
Email: Send Email
Web: www.PushAsRx.com

Push 24/7

Address: 1700 E Cliff Dr
El Paso, TX 79902
Phone: (915) 412-6677
Email: Send Email
Web: www.PushAsRx.com

EVENTS REGISTRATION:  Live Events & Webinars – Sign Up Today ❗️

Additional Online Links & Resources (Available 24/7)

  1. Online Appointments or Consultations:  https://bit.ly/Book-Online-Appointment
  2. Online Physical Injury / Accident Intake Form: https://bit.ly/Fill-Out-Your-Online-History
  3. Online Functional Medicine Assessment: https://bit.ly/functionmed

Disclaimer

The information herein is not intended to replace a one-on-one relationship with a qualified health care professional, licensed physician, and is not medical advice. We encourage you to make your own health care decisions based on your research and partnership with a qualified health care professional. Our information scope is limited to chiropractic, musculoskeletal, physical medicines, wellness, sensitive health issues, functional medicine articles, topics, and discussions. We provide and present clinical collaboration with specialists from a wide array of disciplines. Each specialist is governed by their professional scope of practice and their jurisdiction of licensure. We use functional health & wellness protocols to treat and support care for the musculoskeletal system’s injuries or disorders. Our videos, posts, topics, subjects, and insights cover clinical matters, issues, and topics that relate and support, directly or indirectly, our clinical scope of practice.* Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We provide copies of supporting research studies available to regulatory boards and the public upon request. We understand that we cover matters that require an additional explanation of how it may assist in a particular care plan or treatment protocol; therefore, to further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900 Read More…

Dr. Alex Jimenez DC, MSACP, CCST, IFMCP*, CIFM*, CTG*

email: coach@elpasofunctionalmedicine.com
phone: 915-850-0900
Licensed in Texas & New Mexico

WEBINARS
Online History 24/7
ONLINE HISTORY 24/7
Book Online Chiropractor
BOOK ONLINE 24/7
English EN Spanish ES