Autoimmunity: One of the most common things is to leave the doctor’s office with a diagnosis of an autoimmune disease and no nutritional or lifestyle changing insight. Autoimmune diseases are related to inflammation. Keeping the inflammation down is the goal with autoimmune attacks. The foods you eat make a huge difference in the frequency and severity of flare-ups. Steady dietary changes can help you reach your optimal self.
Is Autoimmune Disease A Result Of The Collective Perturbations Of The Exposome & Its Impact On The Immunometabolic System?
The Exposome
Semin Arthritis Rheum. 2018; 47(5): 710‐717.
Exposome Influence On SLE
The Ecology Of The Exposome
Exposome & The Alteration Of “Self”
The Exposome Connections To Autoimmune Diseases Converting Self Into Non‐Self
- Immunometabolic dysfunctions through diet and lifestyle imbalances
- Gut Ecology and the Microbiome
- ViralorBacterialInfections
- Hormones
- Drugs
- Chemicals
- IonizingRadiation
- PsychologicalStress
FEBS Lett. 2017 Oct;591(19):3119‐3134.
Cell. 2018 Jan 11;172(1‐2):22‐40.
Cross‐Talk Among The Endocrine, Immune & Metabolic Systems
Multi‐Organ Network Biology
In Autoimmunity, Warburg Metabolism Is Increased Through Increased Activity Of GAPDH
Science. 2018; 360: 377‐78. Dietary Influence?
Blocking Immune Cell Glycolysis & “Starving” Its Function
Ketogenic Diet’s Potential Impact On GAPDH Immunometabolic Regulation
Cell. 2018 Jan 11;172(1‐2):162‐175.
Front Immunol. 2017 Mar 21;8:311.
Origin Of IL‐17 Producing Th17 Cells
What Is The Relationship Of The Gut Microbiome To Autoimmune Disease?
Science. 2018 Mar 9;359(6380):1097‐98.
Science. 2018 Mar 9;359(6380):1156‐61.
Allergol Int. 2018 Jan 6;67(1):32‐42.
Int J Mol Sci. 2015 Sep 1;16(9):20841‐58.
Science. 2018 Mar 9;359(6380):1151‐56.
High Fiber Influences On Diabetes In Animal Model
80% Of Patients With Autoimmune Disease Are Female
Why?
Estrogen & Autoimmunity
- The greatest association with autoimmune diseases is the female gender
- 17‐beta estradiol seems to play a role in activating T cells in autoimmune disease
- T cells have ER‐alpha receptors that are activated by 17‐beta estradiol resulting in the production of inflammatory cytokines
- Blocking ER‐alpha receptors may have a beneficial effect on autoimmune activation
Sci Signal. 2018 Apr 17;11(526). piieaap 9415
Eleanor Rogan, PhD IFM Linus Pauling Award Winner
www.JeffreyBland.com
Estrogen & Androgen Metabolism
4‐Hydroxyestrogens & DNA reactivity
Indole‐3‐Carbinol (I3C) Inhibition Of ER‐Alpha
Relationship Of Hepatic Drug Detoxification To Anti‐Nuclear Antibody Development
Biomed Res Int. 2015;2015:194031.
Making Friends With Ourselves: Clinical Implications
- Reduce exposure to agents that activate immunometabolic dysfunction through the exposome
- – Dietary
- – Infection
- – Parasites
- – Xenobiotics
- – Hormone
- – Allergy
- – Specific medications
- – Dysbiosis
- Reduce exposure to DNA damage (radiation, chemicals)
- Support hepatic detoxification
- Implement gastrointestinal restoration program
- Reduce metabolic inflammation and endotoxin
- Reduce psychological stress factors that activate HPA axis
Jeffrey Bland, PhD
Chairman Emeritus & Member, Board of Directors The Institute for Functional Medicine
Purpose & Passions: I am a Doctor of Chiropractic specializing in progressive, cutting-edge therapies and functional rehabilitation procedures focused on clinical physiology, total health, practical strength training, and complete conditioning. We focus on restoring normal body functions after neck, back, spinal and soft tissue injuries.
We use Specialized Chiropractic Protocols, Wellness Programs, Functional & Integrative Nutrition, Agility & Mobility Fitness Training and Cross-Fit Rehabilitation Systems for all ages.
As an extension to effective rehabilitation, we too offer our patients, disabled veterans, athletes, young and elder a diverse portfolio of strength equipment, high-performance exercises and advanced agility treatment options. We have teamed up with the cities premier doctors, therapist and trainers to provide high-level competitive athletes the possibilities to push themselves to their highest abilities within our facilities.
We’ve been blessed to use our methods with thousands of El Pasoans over the last three decades allowing us to restore our patients’ health and fitness while implementing researched non-surgical methods and functional wellness programs.
Our programs are natural and use the body’s ability to achieve specific measured goals, rather than introducing harmful chemicals, controversial hormone replacement, un-wanted surgeries, or addictive drugs. We want you to live a functional life that is fulfilled with more energy, a positive attitude, better sleep, and less pain. Our goal is to ultimately empower our patients to maintain the healthiest way of living.
With a bit of work, we can achieve optimal health together, no matter the age or disability.
Join us in improving your health for you and your family.
It’s all about: LIVING, LOVING & MATTERING! 🍎
Welcome & God Bless
EL PASO LOCATIONS
Central:
6440 Gateway East, Ste B
Phone: 915-850-0900
East Side:
11860 Vista Del Sol, Ste 128
Phone: 915-412-6677
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