Functional Neurology: Akkermansia Muciniphila for Metabolic Syndrome

According to scientists, our gut microbiome may be associated with health issues like metabolic syndrome, including heart disease, stroke, and diabetes. Scientists demonstrated that Akkermansia muciniphila, a culture of bacteria naturally found in the gastrointestinal (GI) tract of healthy people, may be associated with weight loss in humans. While diet and lifestyle modifications are recommended to help regulate metabolic syndrome and its associated health issues, recent research studies determined that using “beneficial” gut bacteria, such as A. muciniphila, may regulate excess weight and obesity.

How A. Muciniphila Can Help Improve Metabolic Syndrome

A research study in the Louvain Drug Research Institute of the University of Louvain and the Cliniques Universitaires Saint-Luc found that A. muciniphila supplements reduced the risk of developing metabolic syndrome and other health issues like heart disease, stroke, and diabetes in people with excess weight and obesity. Scientists are currently preparing larger-scale research studies to market A. muciniphila as a food supplement within the next few years.  Research studies demonstrated that A. muciniphila supplements are a safe and effective intervention for people with excess weight and obesity.  

Other research studies demonstrated the effects of Akkermansia muciniphila in overall health and wellness. In 2007, scientists demonstrated that A. muciniphila can improve the development of obesity and type 2 diabetes in a group of mice. Scientists also found that a pasteurized form of the beneficial gut bacteria improved risk factors, such as insulin resistance. Further research studies are required to determine if supplements of the pasteurized A. muciniphila have the same effects in humans. Scientists also need to evaluate the metabolic effects of A. muciniphila supplements in humans.  

A randomized, double-blind, placebo-controlled pilot research study included 40 participants with excess weight or obesity with insulin resistance. The participants were separated into three different groups which were given daily supplements of either placebo, live A. muciniphila, or pasteurized A. muciniphila, throughout three months. The participants were asked to follow their regular diets and lifestyles without changing what they ate and exercise or physical activity levels. The results of the research study concluded what other research studies had previously demonstrated in the groups of mice.  

According to the research studies, pasteurized A. muciniphila supplements helped improve essential metabolic parameters as well as helped reduce inflammatory markers in the participants. Pasteurized A. muciniphila also considerably helped improve approximately 30 percent of the participant’s insulin sensitivity index compared with the placebo group, however, the live A. muciniphila supplements helped improve insulin resistance score in the participants. The pasteurized A. muciniphila supplements were also associated with a small decrease in body weight and body fat mass in the participants.  

Recent research studies also found that A. muciniphila supplements can help reduce plasma cholesterol levels in mice as well as prevent the development of atherosclerosis in other animal models. Results from current research studies on humans demonstrated that pasteurized A. muciniphila considerably reduced approximately 8.68 percent total cholesterol levels compared with the placebo group while low-density lipoprotein (LDL) or “bad” cholesterol decreased about 7.53 percent and triglycerides decreased about 15.71 percent, however, these results were not ultimately considered significant.  

Compared with the positive effects of A. muciniphila supplements on essential metabolic parameters, the participants in the placebo group had an increased risk of developing insulin resistance and hypercholesterolemia, among other health issues associated with metabolic syndrome as well as heart disease, stroke, and diabetes. Moreover, the research studies demonstrated that taking Akkermansia muciniphila supplements had no noticeable changes in the participant’s gut microbiome. The results show that pasteurized or live A muciniphila supplements did not affect the overall gut microbiome.  

Scientists currently understand that recent research studies did have several limitations, including that these were ultimately small-scale trials which mean that the results didn’t offer definitive conclusions associated with essential metabolic parameters in the participants. Scientists also determined that the results of the research studies didn’t find considerable changes in visceral adiposity and BMI in the participants. However, scientists concluded that the outcome measures did show the feasibility of administering A. muciniphila to humans with metabolic syndrome and its associated health issues.  

According to scientists, our gut microbiome may be associated with health issues like metabolic syndrome, including heart disease, stroke, and diabetes. Approximately 50 million adults in the United States have metabolic syndrome. Fortunately, scientists demonstrated that Akkermansia muciniphila, a culture of bacteria naturally found in the gastrointestinal (GI) tract of healthy people, may be associated with weight loss in humans. Excess weight and obesity can ultimately lead to metabolic syndrome and other health issues like heart disease, stroke, and diabetes. While diet and lifestyle modifications are recommended to help regulate metabolic syndrome and its associated health issues, recent research studies determined that using “beneficial” gut bacteria, such as A. muciniphila, may regulate excess weight and obesity as well as improve essential metabolic parameters. Dr. Alex Jimenez D.C., C.C.S.T. Insight

According to scientists, our gut microbiome may be associated with health issues like metabolic syndrome, including heart disease, stroke, and diabetes. Scientists demonstrated that Akkermansia muciniphila, a culture of bacteria naturally found in the gastrointestinal (GI) tract of healthy people, may be associated with weight loss in humans. While diet and lifestyle modifications are recommended to help regulate metabolic syndrome and its associated health issues, recent research studies determined that using “beneficial” gut bacteria, such as A. muciniphila, may regulate excess weight and obesity.  

The scope of our information is limited to chiropractic, musculoskeletal, and nervous health issues or functional medicine articles, topics, and discussions. We use functional health protocols to treat injuries or disorders of the musculoskeletal system. Our office has made a reasonable attempt to provide supportive citations and has identified the relevant research study or studies supporting our posts. We also make copies of supporting research studies available to the board and or the public upon request. To further discuss the subject matter above, please feel free to ask Dr. Alex Jimenez or contact us at 915-850-0900. 

Curated by Dr. Alex Jimenez  

References:

1. GEN Staff. “Bacterial Supplement May Cut Risk of Heart Disease in Obese People.” GEN, GEN Media, 3 July 2019, www.genengnews.com/news/bacterial-supplement-could-cut-risk-of-cardiovascular-disease-in-overweight-people/.
2. Cani, Patrice D., et al. “Akkermansia Muciniphila Helps Improve Features of Metabolic Syndrome in Overweight and Obese Subjects.” Gut Microbiota for Health, 16 July 2019, www.gutmicrobiotaforhealth.com/en/akkermansia-muciniphila-helps-improve-features-of-metabolic-syndrome-in-overweight-and-obese-subjects/.
3. Depommier, Clara, et al. “Supplementation with Akkermansia Muciniphila in Overweight and Obese Human Volunteers: a Proof-of-Concept Exploratory Study.” Nature Medicine, U.S. National Library of Medicine, July 2019, www.ncbi.nlm.nih.gov/pubmed/31263284.

Neurotransmitter Assessment Form

The following Neurotransmitter Assessment Form can be filled out and presented to Dr. Alex Jimenez. The following symptoms listed on this form are not intended to be utilized as a diagnosis of any type of disease, condition, or any other type of health issue.  

Additional Topic Discussion: Chronic Pain

Sudden pain is a natural response of the nervous system which helps to demonstrate possible injury. By way of instance, pain signals travel from an injured region through the nerves and spinal cord to the brain. Pain is generally less severe as the injury heals, however, chronic pain is different than the average type of pain. With chronic pain, the human body will continue sending pain signals to the brain, regardless if the injury has healed. Chronic pain can last for several weeks to even several years. Chronic pain can tremendously affect a patient’s mobility and it can reduce flexibility, strength, and endurance.  

Neural Zoomer Plus for Neurological Disease

Dr. Alex Jimenez utilizes a series of tests to help evaluate neurological diseases. The Neural Zoomer^TM Plus is an array of neurological autoantibodies which offers specific antibody-to-antigen recognition. The Vibrant Neural Zoomer^TM Plus is designed to assess an individual’s reactivity to 48 neurological antigens with connections to a variety of neurologically related diseases. The Vibrant Neural Zoomer^TM Plus aims to reduce neurological conditions by empowering patients and physicians with a vital resource for early risk detection and an enhanced focus on personalized primary prevention.  

Food Sensitivity for the IgG & IgA Immune Response

Dr. Alex Jimenez utilizes a series of tests to help evaluate health issues associated with a variety of food sensitivities and intolerances. The Food Sensitivity Zoomer^TM is an array of 180 commonly consumed food antigens that offers very specific antibody-to-antigen recognition. This panel measures an individual’s IgG and IgA sensitivity to food antigens. Being able to test IgA antibodies provides additional information to foods that may be causing mucosal damage. Additionally, this test is ideal for patients who might be suffering from delayed reactions to certain foods. Utilizing an antibody-based food sensitivity test can help prioritize the necessary foods to eliminate and create a customized diet plan around the patient’s specific needs.  

Gut Zoomer for Small Intestinal Bacterial Overgrowth (SIBO)

Dr. Alex Jimenez utilizes a series of tests to help evaluate gut health associated with small intestinal bacterial overgrowth (SIBO). The Vibrant Gut Zoomer^TM offers a report that includes dietary recommendations and other natural supplementation like prebiotics, probiotics, and polyphenols. The gut microbiome is mainly found in the large intestine and it has more than 1000 species of bacteria that play a fundamental role in the human body, from shaping the immune system and affecting the metabolism of nutrients to strengthening the intestinal mucosal barrier (gut-barrier). It is essential to understand how the number of bacteria that symbiotically live in the human gastrointestinal (GI) tract influences gut health because imbalances in the gut microbiome may ultimately lead to gastrointestinal (GI) tract symptoms, skin conditions, autoimmune disorders, immune system imbalances, and multiple inflammatory disorders.  

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