Is It Really Autoimmunity? | El Paso, TX. | Part II

Autoimmunity: One of the most common things is to leave the doctor’s office with a diagnosis of an autoimmune disease and no nutritional or lifestyle changing insight. Autoimmune diseases are related to inflammation. Keeping  the inflammation down is the goal with autoimmune attacks. The foods you eat make a huge difference in the frequency and severity of flare-ups. Steady dietary changes can help you reach your optimal self.

Is Autoimmune Disease A Result Of The Collective Perturbations Of The Exposome & Its Impact On The Immunometabolic System?

science.sciencemag.org/content/330/6003/460.summary?sid=1ab5a992-4406-499c-b24f-6e7a46c1dc95%5B/caption%5D

The Exposome

Semin Arthritis Rheum. 2018; 47(5): 710‐717.

Exposome Influence On SLE

The Ecology Of The Exposome

Exposome & The Alteration Of “Self”

The Exposome Connections To Autoimmune Diseases Converting Self Into Non‐Self

• Immunometabolic dysfunctions through diet and lifestyle imbalances
• Gut Ecology and the Microbiome
• ViralorBacterialInfections
• Hormones
• Drugs
• Chemicals
• IonizingRadiation
• PsychologicalStress

FEBS Lett. 2017 Oct;591(19):3119‐3134.

Cell. 2018 Jan 11;172(1‐2):22‐40.

Cross‐Talk Among The Endocrine, Immune & Metabolic Systems

Multi‐Organ Network Biology

In Autoimmunity, Warburg Metabolism Is Increased Through Increased Activity Of GAPDH

Science. 2018; 360: 377‐78. Dietary Influence?

Blocking Immune Cell Glycolysis & “Starving” Its Function

Science. 2018; 360: 449‐54.

Ketogenic Diet’s Potential Impact On GAPDH Immunometabolic Regulation

Cell. 2018 Jan 11;172(1‐2):162‐175.

Gut Microbes. 2016;7(1):82‐9.

Front Immunol. 2017 Mar 21;8:311.

Origin Of IL‐17 Producing Th17 Cells

What Is The Relationship Of The Gut Microbiome To Autoimmune Disease?

www.cell.com/cell/issue?pii=S0092-8674(17)X0006-8%5B/caption%5D

Science. 2018 Mar 9;359(6380):1097‐98.

Science. 2018 Mar 9;359(6380):1156‐61.

Allergol Int. 2018 Jan 6;67(1):32‐42.

Int J Mol Sci. 2015 Sep 1;16(9):20841‐58.

Science. 2018 Mar 9;359(6380):1151‐56.

High Fiber Influences On Diabetes In Animal Model

80% Of Patients With Autoimmune Disease Are Female

Why?

Estrogen & Autoimmunity

• The greatest association with autoimmune diseases is the female gender
• 17‐beta estradiol seems to play a role in activating T cells in autoimmune disease
• T cells have ER‐alpha receptors that are activated by 17‐beta estradiol resulting in the production of inflammatory cytokines
• Blocking ER‐alpha receptors may have a beneficial effect on autoimmune activation

Sci Signal. 2018 Apr 17;11(526). piieaap 9415

Eleanor Rogan, PhD IFM Linus Pauling Award Winner

www.JeffreyBland.com

Estrogen & Androgen Metabolism

4‐Hydroxyestrogens & DNA reactivity

www.ncbi.nlm.nih.gov/pubmed/22155198%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/21432907%5B/caption%5D

Indole‐3‐Carbinol (I3C) Inhibition Of ER‐Alpha

www.ncbi.nlm.nih.gov/pubmed/27312859%5B/caption%5D

Relationship Of Hepatic Drug Detoxification To Anti‐Nuclear Antibody Development

onlinelibrary.wiley.com/doi/pdf/10.1002/art.1780240805%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/24763537%5B/caption%5D

Biomed Res Int. 2015;2015:194031.

www.ncbi.nlm.nih.gov/pmc/articles/PMC4365752/%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/18995849%5B/caption%5D

www.ncbi.nlm.nih.gov/pubmed/24530186%5B/caption%5D

Making Friends With Ourselves: Clinical Implications

• Reduce exposure to agents that activate immunometabolic dysfunction through the exposome
• – Dietary
• – Infection
• – Parasites
• – Xenobiotics
• – Hormone
• – Allergy
• – Specific medications
• – Dysbiosis
• Reduce exposure to DNA damage (radiation, chemicals)
• Support hepatic detoxification
• Implement gastrointestinal restoration program
• Reduce metabolic inflammation and endotoxin
• Reduce psychological stress factors that activate HPA axis

Jeffrey Bland, PhD

Chairman Emeritus & Member, Board of Directors The Institute for Functional Medicine