Is It Really Autoimmunity? | El Paso, TX. | Part I
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The western diet is associated with inflammation, and inflammation is central to autoimmunity and autoimmune diseases. Keeping the inflammation down can help in lengthening time between attacks. What to eat and what not to eat are the common questions. In order to quiet inflammation triggers, educate ourselves and live a normal life is the focus.
Table of Contents
My 2006 Seminar Series
“Understanding the Origins of Autoimmune Diseaseâ€
Autoimmunity:
The Central Question I Asked In This series,
Are We Allergic to Ourselves?
– Autoantibodies
– Are they really “autoantibodies�
– Self or Nonâ€self?
I would like to reâ€explore this question using what we have learned in 2018.
Presence of Antiâ€Chromatin, DNA and RNA Antibodies
What Biological Processes May Make Self Into Nonâ€Self?
Postâ€translationalmodificationofProtein – Glycation of protein – Protein Oxidation – Amino Acid Conjugation of Protein (Citrullinated Protein/AntiCCP and RA)
ProteinSynthesisErrors
DNA and RNA Changes – Radiation Induced Crosslinking of DNA – Oxidation of DNA – Copy Errors not corrected by DNA repair process – Epigenetic Changes (the methylome)
Where Do Antiâ€Cyclic Citrullinated Peptides (AntiCCPs) Come From?
Activation of the immune system resulting in increased iNOS production of nitric oxide
Arginine residues in proteins can be converted in situ into citrulline with the release of nitric oxide by iNOS
The citrulline produced in the protein is now “foreign†and can be recognized by the immune system as such
Antibodies can then be produced against this “foreign proteinâ€
Disease Modifying Antiâ€Rheumatic Drugs (DMARDs)
The Facts on Methotrexate For Rheumatoid Arthritis Treatment
Methotrexate is the most commonly prescribed drug to treat rheumatoid arthritis, yet it only helps about half of those who try it. Find out how it works and how to lessen its side effects.
Folate Inhibition To Block Immune Cell Proliferation