Chronic Musculoskeletal Pain Treatment Strategies that Work

Exercise, Manual Care, Acupuncture, and Electroacupuncture: What Does the Evidence Say About Chronic Musculoskeletal Pain?

Abstract: Chronic musculoskeletal pain rarely has one universal solution. Exercise, manual or chiropractic care, acupuncture, and electroacupuncture aim at different clinical targets and carry different levels of evidence. The most defensible treatment plan is not the one with the most therapies; it is the one that links each intervention to a diagnosis, measurable goal, patient preference, and reassessment plan.

The Better Question Is Not “Which Treatment Wins?”

An engineer with chronic low-back pain may ask whether exercise is more scientific than chiropractic care. A programmer with persistent neck pain may wonder whether acupuncture is merely an alternative to rehabilitation. Another patient may hear “electroacupuncture” and assume that adding electrical stimulation must make acupuncture stronger.

Evidence-based care is not a tournament. Chronic musculoskeletal pain includes different conditions, mechanisms, activity limits, and patient goals. Low-back pain, knee osteoarthritis, tendinopathy, myofascial pain, and nerve-related symptoms are not interchangeable diagnoses. A treatment that helps one condition may have weak evidence for another.

That is why modern guidelines increasingly emphasize individualized, multimodal care. For chronic primary low-back pain, the World Health Organization supports structured exercise, needling therapies such as acupuncture, and spinal manipulative therapy as options within a broader plan, while also noting that certainty varies across interventions (World Health Organization, 2023).

Exercise: Building Capacity, Not Just Reducing Pain

Exercise has a straightforward biological purpose: improve the body’s ability to tolerate load. Depending on the diagnosis, that may mean strengthening spinal muscles, improving hip control, increasing tendon capacity, restoring aerobic fitness, or practicing movements needed for work and daily life.

A Cochrane review of 249 trials found moderate-certainty evidence that exercise improves pain in chronic nonspecific low-back pain compared with no treatment, usual care, or placebo. Functional gains were smaller, and results varied across exercise types and study designs (Hayden et al., 2021). Reviews of osteoarthritis guidelines also show unusually consistent support for exercise and education, especially for knee and hip osteoarthritis (Gibbs et al., 2023).

Exercise therefore earns a central role because it can create adaptation. However, “exercise works” does not mean every program works equally well for every patient. Dose, progression, adherence, fear of movement, sleep, job demands, and the underlying diagnosis all influence results.

What the patient gains

A successful exercise plan may improve:

• strength and endurance,
• tolerance for sitting, lifting, walking, or climbing,
• confidence with movement,
• joint control and balance,
• and resilience against future workload.

These are capacity outcomes, not simply changes on a pain scale.

Manual and Chiropractic Care: A Tool for Symptoms and Function

Manual care includes several approaches, such as joint mobilization, spinal manipulation, and other hands-on techniques. Chiropractic treatment may include these procedures alongside exercise, education, and rehabilitation.

The evidence is nuanced. A 2026 Cochrane review found that spinal manipulative therapy for chronic low-back pain may provide small improvements in pain and function compared with sham care and larger differences compared with no treatment. When compared with other conservative treatments, however, differences were small. The certainty of evidence was generally low to very low because trials used different techniques, treatment doses, populations, and comparison groups (de Zoete et al., 2026).

That finding supports a practical interpretation: manual care can be reasonable when mobility restrictions, mechanical pain, or short-term symptom reduction are clinically relevant, but it should not be presented as a universal replacement for active rehabilitation.

Acupuncture: Pain Modulation With Condition-Specific Evidence

Acupuncture uses thin needles placed at selected points. Research suggests that needling can influence sensory input and pain-processing networks, but no single mechanism fully explains clinical outcomes. The important question is whether patients experience meaningful improvements in pain, function, or both.

An individual-patient-data meta-analysis involving 20,827 participants found acupuncture superior to both sham acupuncture and no-acupuncture controls across several chronic pain conditions, including musculoskeletal pain and osteoarthritis. The difference between true and sham acupuncture was smaller than the difference between acupuncture and no treatment, suggesting that both specific needling effects and contextual treatment effects contribute to outcomes (Vickers et al., 2018).

For chronic low-back pain, a 2025 Cochrane overview concluded that acupuncture probably reduces pain and slightly improves function compared with no treatment, while benefits versus sham or usual care are generally smaller (Rizzo et al., 2025).

This does not make acupuncture a substitute for diagnosis, strength training, or progressive loading. It makes acupuncture a potential adjunct when pain sensitivity, muscle tension, or symptom irritability is limiting participation in rehabilitation.

Electroacupuncture: Similar Needles, Added Electrical Stimulation

Electroacupuncture connects inserted acupuncture needles to a device that delivers a controlled electrical current. Frequency, intensity, pulse width, needle location, and treatment duration can all vary. That variability is one reason results from different studies are difficult to combine.

In a randomized trial of 121 adults with chronic low-back pain, electroacupuncture did not significantly outperform sham electroacupuncture for the primary pain-intensity outcome. It did, however, produce greater improvement in back-specific disability, a secondary outcome (Kong et al., 2020). Reviews in knee osteoarthritis have reported favorable results, but study quality, comparator choice, blinding, and protocol differences remain important limitations (Li et al., 2023).

The conclusion should remain modest in practice. Electroacupuncture may be useful for selected chronic musculoskeletal pain presentations, but evidence does not justify assuming it is always superior to manual acupuncture or that more electrical intensity automatically produces a better clinical result.

Why Combining Treatments Can Make Sense

Multimodal care is rational when each component has a different job. One possible plan might use manual care to improve movement tolerance, acupuncture or electroacupuncture to help control persistent pain, and exercise to rebuild strength and capacity.

That combination should still answer four questions:

• What diagnosis or working diagnosis is being treated?
• What specific problem is each intervention targeting?
• What outcome will show that the intervention is helping?
• When will the plan be changed if progress stalls?

Evidence Quality Matters as Much as the Treatment Name

Scientific readers should look beyond whether a study reports a statistically significant result. Important questions include sample size, risk of bias, quality of blinding, type of control group, duration of follow-up, effect size, and whether the change is clinically meaningful.

Chronic pain trials are especially difficult because patients cannot always be blinded to exercise or hands-on treatment. Sham acupuncture can also produce sensory effects, which makes it an imperfect placebo. Manual therapy protocols vary substantially between clinicians. Exercise trials differ in intensity, supervision, and adherence.

These limitations do not mean the treatments are ineffective. They mean certainty should match the quality of the evidence.

Diagnosis Comes Before Modality

Persistent pain deserves an examination before a treatment menu. Clinicians should consider neurological deficits, progressive weakness, fracture risk, inflammatory disease, infection, systemic illness, significant trauma, and other red flags when appropriate. Imaging or laboratory testing should be driven by history and examination rather than ordered automatically.

At Injury Medical Clinic PA in El Paso, Dr. Alex Jimenez, DC, APRN, FNP-BC, CFMP, IFMCP, bridges chiropractic physical medicine, medical diagnostics, functional medicine, and rehabilitation. Dr. Maria Guadalupe Cardenas, MD, a board-certified internal medicine physician with more than 40 years of experience, provides medical direction, risk stratification, and collaborative oversight. This coordinated model supports disciplined selection of rehabilitation, manual care, diagnostics, and adjunctive therapies without assuming every patient needs every service.

This approach supports beneficence through defined clinical benefit, non-maleficence through appropriately screened conservative care, and autonomy through understandable evidence, alternatives, uncertainties, and measurable goals. Acupuncture or electroacupuncture may be added when appropriate but should not delay evaluation of serious disease or replace progressive rehabilitation when capacity is the main problem.

The Evidence-Based Bottom Line

For chronic musculoskeletal pain, exercise is usually the clearest route to rebuilding physical capacity. Manual or chiropractic care may help selected patients with pain, mobility, and function. Acupuncture has credible evidence for several chronic pain conditions, although average effects versus sham are modest. Electroacupuncture may add value in some patients, but the evidence base is narrower and should be interpreted cautiously.

Multidisciplinary CTA

If chronic back, neck, joint, or musculoskeletal pain is limiting work, sleep, exercise, or daily movement, consider an integrated evaluation that examines both mechanical and medical contributors. A coordinated plan can determine whether rehabilitation, chiropractic/manual care, acupuncture, electroacupuncture, medical testing, or another pathway fits your findings and preferences.

Enhancing Health Together: Embracing Multidisciplinary Evaluation and Treatment” | El Paso, TX

References

Gibbs, A. J., Gray, B., Wallis, J. A., Taylor, N. F., Kemp, J. L., Hunter, D. J., & Barton, C. J. (2023). Recommendations for the management of hip and knee osteoarthritis: A systematic review of clinical practice guidelines. Osteoarthritis and Cartilage, 31(10), 1280–1292.

de Zoete, A., Innocenti, T., Petrozzi, M. J., van Middelkoop, M., Assendelft, W. J. J., de Boer, M. R., van Tulder, M. W., & Rubinstein, S. M. (2026). Spinal manipulative therapy for adults with chronic low back pain. Cochrane Database of Systematic Reviews, 2026(1), CD008112.

Hayden, J. A., Ellis, J., Ogilvie, R., Malmivaara, A., & van Tulder, M. W. (2021). Exercise therapy for chronic low back pain. Cochrane Database of Systematic Reviews, 2021(9), CD009790.

Kong, J. T., Puetz, C., Tian, L., Haynes, I., Lee, E., Stafford, R. S., Manber, R., & Mackey, S. (2020). Effect of electroacupuncture vs sham treatment on change in pain severity among adults with chronic low back pain: A randomized clinical trial. JAMA Network Open, 3(10), e2022787.

Rizzo, R. R. N., Cashin, A. G., Wand, B. M., Ferraro, M. C., Sharma, S., Lee, H., O’Hagan, E., Maher, C. G., Furlan, A. D., van Tulder, M. W., & McAuley, J. H. (2025). Non-pharmacological and non-surgical treatments for low back pain in adults: An overview of Cochrane reviews. Cochrane Database of Systematic Reviews, 2025(3), CD014691.

Vickers, A. J., Vertosick, E. A., Lewith, G., MacPherson, H., Foster, N. E., Sherman, K. J., Irnich, D., Witt, C. M., & Linde, K. (2018). Acupuncture for chronic pain: Update of an individual patient data meta-analysis. The Journal of Pain, 19(5), 455–474.

Li, P., Zhang, Y., Li, F., Cai, F., Xiao, B., & Yang, H. (2023). The efficacy of electroacupuncture in the treatment of knee osteoarthritis: A systematic review and meta-analysis. Advanced Biology, 7(10), e2200304.

World Health Organization. (2023). WHO guideline for non-surgical management of chronic primary low back pain in adults in primary and community care settings. World Health Organization.